Grup A
- Fenerbahce 2-1 Manchester United
- Gol: Sow 2, Lens 59 – Rooney 89
- Zorya 1-1 Feyenoord
- Gol: Rafael Forster 44 – Jorgensen 15
Grup B
- APOEL 1-0 Young Boys
- Gol: Soteriou 69
- Astana 1-1 Olympiakos
- Gol: Despotovic 8 – Seba 29
Grup C
- Anderlecht 6-1 Mainz 05
- Gol: Stanciu 9, 41, Tielemans 62, Teodorczyk 89, 90+4-pen, Bruno 90+2 – De Blasis 15
- Qabala 1-2 Saint-Etienne
- Gol: Qurbanov 39 – Tannane 45+1, Beric 53
Grup D
- Maccabi Tel Aviv 0-0 AZ Alkmaar
- Gol: –
- Zenit St Petersburg 2-1 Dundalk
- Gol: Giuliano 42, 78 – Horgan 52
Grup E
- Astra 1-1 Viktoria Plzen
- Gol: Stan 19 – Krmencik 25
- Austria Wina 2-4 AS Roma
- Gol: Kayode 2, Grunwald 89 – Dzeko 4, 65, De Rossi 18, Nainggolan 78
Grup F
- Athletic Bilbao 5-3 KRC Genk
- Gol: Aduriz 8, 24-pen, 44-pen, 74, 90+4-pen – Bailey 28, Ndidi 51, Susic 79
- Sassuolo 2-2 Rapid Wina
- Gol: Defrel 34, Pellegrini 45+3 – Jelic 85, Kvilitaia 90
GRUP G – L
